Welcome to the datamonkey.org resource for recombination analysis of multiple sequence alignments using genetic algorithms (GARD) maintained by Sergei L Kosakovsky Pond and the viral evolution group at the Antivirial Research Center of University of California, San Diego.

GARD [methodology PDF] uses an efficient genetic algorithm, implemented within the HyPhy software package that runs on our computer cluster. It can scan an alignment for evidence of discordant phylogenetic signal and answer the following questions:

1. Are there any recombinant sequences in the alignment?
2. How many non-recombinant fragments are there?
3. Where are the breakpoints and what confidence do I have in their location?
4. What phylogenetic trees describe the evolution of each non-recombinant fragment?

Presently, GARD accepts uploads of DNA (or RNA) alignments with 3 to 50 sequences and up to 50000 nucleotides. We may adjust this number depending on the availability of computing resources.

Choose a sequence file:

Data Formats  Samples[Recombinant] [Non-Recombinant]

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